Today I presented a paper from Liam’s group: “A new look at state-space models for neural data”, Paninski et al, JCNS 2009

The paper presents a high-level overview of state-space models for neural data, with an emphasis on statistical inference methods. The basic setup of these models is the following:

• Latent variable defined by dynamics distribution:

• Observed variable defined by observation distribution: .

These two ingredients ensure that the joint probability of latents and observed variables is

.

A variety of applications are illustrated (e.g., = common input noise; = multi-neuron spike trains).

The two problems we’re interested in solving, in general, are:

**(1)** Filtering / Smoothing: inferring from noisy observations , given the model parameters .

**(2)** Parameter Fitting: inferring from observations .

The “standard” approach to these problems involves: (1) recursive approximate inference methods that involve updating a Gaussian approximation to using its first two moments; and (2) Expectation-Maximization (EM) for inferring . By contrast, this paper emphasizes: (1) exact maximization for , which is tractable in via Newton’s Method, due to the banded nature of the Hessian; and (2) direct inference for using the Laplace approximation to . When the dynamics are linear and the noise is Gaussian, the two methods are exactly the same (since a Gaussian’s maximum is the same as its mean; the forward and backward recursions in Kalman Filtering/Smoothing are the same set of operations needed by Newton’s method). But for non-Gaussian noise or non-linear dynamics, the latter method may (the paper argues) provide much more accurate answers with approximately the same computational cost.

Key ideas of the paper are:

- exact maximization of a log-concave posterior
- computational cost, due to sparse (tridiagonal or banded) Hessian.
- the Laplace approximation (Gaussian approximation to the posterior using its maximum and second-derivative matrix), which is (more likely to be) justified for log-concave posteriors
- log-boundary method for constrained problems (which preserves sparsity)

**Next week:** we’ll do a basic tutorial on Kalman Filtering / Smoothing (and perhaps, EM).

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