Context-dependent computation by recurrent dynamics in prefrontal cortex

The past two lab meetings have focused on understanding the regression subspace analysis performed in Mante et al. 2013.

Context-Dependent Computation by Recurrent Dynamics in Prefrontal Cortex
Mante, Sussillo, Shenoy & Newsome; Nature 2013

The paper explores the hypothesis that context-dependent behavior is the result of early selection. However, they find no evidence for early selection mechanisms. Instead, they demonstrate that populations of neurons in the PFC can be projected into a neural state space in which the features of the task are separable regardless of context.

As we study larger populations of neurons in increasingly complex tasks, we must address the problem of how to meaningfully visualize and interrogate our data. This is a difficult challenge and Mante et al. 2013 provides a compelling approach.

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