Context-dependent computation by recurrent dynamics in prefrontal cortex

The past two lab meetings have focused on understanding the regression subspace analysis performed in Mante et al. 2013.

Context-Dependent Computation by Recurrent Dynamics in Prefrontal Cortex
Mante, Sussillo, Shenoy & Newsome; Nature 2013

The paper explores the hypothesis that context-dependent behavior is the result of early selection. However, they find no evidence for early selection mechanisms. Instead, they demonstrate that populations of neurons in the PFC can be projected into a neural state space in which the features of the task are separable regardless of context.

As we study larger populations of neurons in increasingly complex tasks, we must address the problem of how to meaningfully visualize and interrogate our data. This is a difficult challenge and Mante et al. 2013 provides a compelling approach.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s